ANIMAL CS ADULTERATIONS

Animal-derived CS is often exposed to voluntary adulteration by similar artificial compounds such as cheaper polysaccharides and substances that cannot be determined with usual analytical controls utilized in the nutraceutical industry.

Chondroitin Sulfate is now acknowledged within the nutraceuticals industry as one of the most adulterated supplements in the market, a problem which is widespread, deteriorating and increasing. Furthermore, the extent of adulteration is probably underestimated, with much of the adulteration going undetected, encouraged and abetted by the lack of industry-wide validated methods.

ARTIFICIAL POLYMERS

  • Carrageenan
  • Surfactants
  • Cheaper polysaccarides: glucomannan
  • Sodium alginate
  • Propylene glycol alginate sulfate sodium
  • Alginic sodium diester

Not well identified other adulterans?

Chemical adulterants can be separated from animal CS by their difference in electrophoretic mobility or other specific analytical approaches, but not with common largely used methods. As a consequence, raw materials and dietary supplement products contain less than the claimed amount of CS and, in some cases, only 5-10%, which is a huge fraud to clients, traders and consumers.

Mythocondro® has an homogeneous structure and physicochemical properties; the high purity with point-by-point controlled production process offers a highly controlled and reproducible final product, with no toxicity in acute and chronic animal models, improved biological activities, anti-inflammatory and protective properties in an osteoarthritis animal model study. This avoid all problems linked to mislabeling and reduction of clinical efficacy of final products.

ANIMAL DERIVED CS > QUALITY CONCERNS OVERVIEW

EFFICACY
Recent meta-analysis has demonstrated variable effects on osteoarthritis symptoms, yielding conflicting results mainly due to the high variability and poor quality of products used depending on the animal source. [McAlindon TE et al., JAMA 2000; 283: 1469–1475.]
MISLABELING
Several published studies report that the quality of CS present in several nutraceuticals is poor. [Volpi N., Food Anal Meth 2008; Volpi, Separation Sci 2009]
BIOAVAILABILITY
Absorption and bioavailability of the various CS formulations is strongly influenced by the structure and characteristics of the parental molecules, such as molecular mass, charge density, and cluster of disulfated disaccharides [Volpi N. Ost Cartil 2003].
SAFETY
Potential consumer safety problems → presence of transmissible infective agents (viruses and prions) OR unidentified protein contamination potentially responsible for allergenic reactions
RESTRICTION
A restriction use related to religious and supply issues.